SIGNIFY® Bioactive’s components are designed to recruit and signal osteoblasts that help promote bone formation. SIGNIFY® provides an osteoconductive matrix for new bone growth and contains activating chemistry that attracts and stimulates bone cells.
Features and Benefits
Cell Recruitment and Signaling
The regeneration of damaged tissue involves the migration and proliferation of osteoblasts to the graft site. Bioglass recruits these cells and stimulates the production of growth factors that amplify the activity of osteoblasts responsible for bone formation.1, 2, 3
No Preparation Necessary
SIGNIFY® may be used right out of the syringe without mixing with autograft or BMA.
The moldability of SIGNIFY® allows it to be shaped and sized to fit an osseous void.
1 Xynos ID, Edgar AJ, Buttery LDK, Hench LL, Polak JM. Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochem. Biophys. Res.Commun. 2000; 276: 461–465.
2 Xynos ID, Hukkanen MV, Batten JJ, Buttery LD, Hench LL, Polak JM. Bioglass 45S5 Stimulates Osteoblast Turnover and Enhances Bone Formation In Vitro: Implications and Applications for Bone Tissue Engineering. Calcif. Tissue Int. 2000; 67:321–329.
3 Ducheyne P, Qiu Q: Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function. Biomaterials 1999; 20: 2287–2303.