KINEX® and KINEX® PLUS Bioactive Bone Void Filler
KINEX® and KINEX® PLUS Bioactive’s components are designed to recruit and signal osteoblasts, promote early vascular development and bind proteins necessary for bone regeneration. KINEX® uses The Power of Bioactive Glass® to help promote bone formation and healing in the posterolateral spine, pelvis and extremities.
Features and Benefits
Cell Recruitment and Signaling
The regeneration of damaged tissue involves the migration and proliferation of osteoblasts to the graft site. Bioglass recruits these cells and stimulates the production of growth factors that amplify the activity of osteoblasts responsible for bone formation. (1, 2, 3)
Hyaluronic acid has been shown to help promote early vascularization and attract osteogenic precursor cells, which may lead to earlier bone formation. (4, 5)
The moldability of KINEX allows it to be shaped and sized to fit an osseous void.
Xynos ID, Edgar AJ, Buttery LDK, Hench LL, Polak JM. Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochem. Biophys. Res. Commun. 2000; 276: 461–465.
Xynos ID, Hukkanen MV, Batten JJ, Buttery LD, Hench LL, Polak JM, Bioglass 45S5 Stimulates Osteoblast Turnover and Enhances Bone Formation In Vitro: Implications and Applications for Bone Tissue Engineering. Calcif. Tissue Int. 2000; 67: 321–329.
Ducheyne P, Qiu Q: Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function. Biomaterials 1999; 20: 2287–2303.
Sasaki T, Watanabe C. Stimulation of osteoinduction in bone wound healing by high-molecular weight hyaluronic acid. Bone 1995; 16: 9–15.
West DC, Hampson IN, Arnold F, Kumar S. Angiogenesis induced by degradation products of hyaluronic acid. Science 1985; 14: 1324–1326.