HEDRON_Logo_White_2021

THE FACE OF FUSION

ACDF | ALIF | LLIF | PLIF | TLIF

HEDRON® 3D printed titanium interbody spacers feature a biomimetic porous scaffold designed to promote bone formation onto and through the implant.

TRABECULAR BONE
INSPIRED DESIGN

Osseointegration between an implant and surrounding bone may help achieve stability. HEDRON® integrates biomimetic architecture with characteristics of established interbody fusion devices.

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MicroCT of trabecular bone
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SEM image of HEDRON®
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Clear visualization

Supplemental fixation required.

FEATURES

Lattice stiffness comparable to trabecular bone1

70% porosity

Expansive pore size distribution

Roughened surface texture

1. Mechanical study data on file.

Strength and Porosity

Unlike first generation 3D printed implants (grid and open architecture), HEDRON® strikes the ideal balance of strength and porosity through a sturdy frame and pore size distribution similar to trabecular bone.

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Grid

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Open architecture

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HEDRON®

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ONGROWTH

<300μm

Small pores (<300μm) are recommended to support initial surface adhesion2

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BONE FORMATION

>300μm

Large pores (>300μm) have been shown to lead to direct osteogenesis3

2. Torres-Sanchez et al. Material Science and Engineering. 2017 Mar; 219–228.
3. KKarageorgiou V, Kaplan D. Biomaterials. 2005;26(27):5474-91.

ENCOURAGES CELLULAR
RESPONSE

In Vitro testing demonstrated that HEDRON® generated a greater expression of Vascular Endothelial Growth Factor (VEGF) and Osteocalcin, two biological indicators of bone formation when seeded with osteoblasts.4

OsteocalcinGeneExpression
VascularEndothelialGrowthFactor

SEM images of cell proliferation at 21 days (500x magnification)

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PEEK

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TAV

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HEDRON®

4. Cell study data on file.

PROMOTES BONE
FORMATION

Unlike PEEK and TAV, the porous architecture of HEDRON® allows for bone to grow through the spacer walls and incorporate into the fusion mass. In a pre-clinical ovine study, HEDRON® implants showed significantly more bone growth compared to PEEK and titanium implants at 6-weeks post-op.5

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Implant
titanium

A pre-clinical sheep interbody study using HEDRON®, Titanium (Ti), and PEEK implants was performed to compare bone ingrowth and ongrowth.

AtLeast51%
AtLeast175%

5. Animal study data on file.

*p<0.05 vs PEEK.

†p<0.05 vs TAV

Accommodates Multiple Approaches and Techniques

Procedure HEDRON® Spacer Footprint Heights Lordosis
ACDF HEDRON C

HEDRON C®

12x14, 14x16, 15x18mm 5, 6, 7, 8, 9, 10, 11, 12mm 0°, 7°, 12°, 15°, 20°
HEDRON IC

HEDRON IC®

12x14, 14x16, 15x18mm 5, 6, 7, 8, 9, 10, 11, 12mm 0°, 7°, 12°
ALIF HEDRON A

HEDRON A

22x29, 24x35, 28x39mm 9, 11, 13, 15, 17, 19, 21mm 8°, 15° and 20°
HEDRON IA

HEDRON IA®

24x30, 26x34, 29x39mm 11, 13, 15, 17, 19, 21mm 8°, 15°, 20°, 25°, and 30°
LLIF HEDRON L

HEDRON L®

18, 22mm widths 40–60mm heights 7, 9, 11, 13, 15mm 10°, 15°
PLIF HEDRON P

HEDRON P®

8x22, 10x22, 10x26, 10x30, 12x26, 12x30mm 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17mm 8°, 15°
TLIF HEDRON T

HEDRON T

10x28, 11x33mm 7, 8, 9, 10, 11, 12, 13, 15, 17mm 8°, 15°