The RETRIEVE™ Bone Marrow Aspiration (BMA) Kit is designed for optimal aspiration of bone marrow from the iliac crest or vertebral body. The Kit provides a convenient system to extract and mix bone marrow with a bone void filler. BMA mixed with NuBone^® and MicroFuse^® provides additional osteogenic cells that can enhance the potential for fusion.

• Optimal Aspiration: Eight holes in the aspiration needle allow for optimal bone marrow aspiration. This minimizes needle repositioning, resulting in less disruption of the iliac crest.

• Convenient Kit Design: The RETRIEVE™ BMA Kit is a complete kit with additional mixing bowl and spatula.

• Clinical Benefits of BMA: BMA mixed with bone graft extenders and bone void fillers enhances the potential for fusion by providing an osteogenic bone graft material that contains native mesenchymal stem cells.

The RETRIEVE™ Bone Graft Harvest System is a minimally invasive option for harvesting autogenous bone from the iliac crest. These cores can be used for general bone grafting or to fill cervical or lumbar interbody fusion devices.

• Minimally Invasive Approach: The RETRIEVE™ bone graft harvesting technique removes the graft through an incision slightly larger than that required for collecting bone marrow aspirate.

• Reduced Pain: The small incision and graft harvest site may help to minimize post-operative pain. Additionally, the easy to use instrumentation may help reduce the time required to harvest iliac crest bone.

• Clinical Benefits of Autograft: Autograft is considered the gold standard of bone grafts because it contains the patient's bone cells (osteoblats), proteins (bone morphogenetic proteins), and a calcified matrix; all factors that help stimulate bone formation and fusion.

MicroFuse^® is a highly engineered bone void filler with the ideal porosity and strength to provide the optimal environment for bone regeneration. MicroFuse^®'s three-dimensional osteoconductive structure is comprimised of many microspheres of bioresorbable polymer bonded together to form an implant with an unique set of properties.

• Optimized Porosity: Designed to provide the most functional porosity for bone to grow on, in, and through the 100% interconnected implant.

• Superior Strength: With a comprehensive strength 8 to 12 times stronger than leading products^• ,MicroFuse^® won't crush during normal intra-operative handling, maintaining porosity necessary for bone growth.

• Resorption to Match Bone Growth: Unique two phase resorption retains three-dimensional structure to provide increased porosity as bone regenerates.

^• Vipin Kunjachan, M.S., Mark Borden, Ph.D. Evaluation of the Structure and Properties of Various Commercially Available Bone Void Fillers. Report on file at Globus Medical, Inc. 2009.

NuBone^® DBM Putty is a moldable, demineralized bone matrix (DBM) composed of 100% allograft tissue (osteoinductive DBM and a unique cortical bone gelatin). The putty contains no artificial additives or synthetics that can reduce DBM osteoinductivity, is moldable and resists irrigation and migration. NuBone^® DBM Putty is packaged in an open-bore syringe for easy delivery.

NuBone^® DBM Gel is a gelatinous demineralized bone matrix (DBM) composed of 100% allograft tissue (osteoinductive DBM and a unique cortical bone gelatin). The gel contains no artificial additives or synthetics that can reduce DBM osteoinductivity. It is designed to be mixed with other bone grafts. The extrudable DBM bone is packaged in a modified luer-lock syringe for easy delivery.